SUPPRESSION OF SIMIAN IMMUNODEFICIENCY VIRUS-REPLICATION BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSDOMINANT NEGATIVE REV MUTANTS

We demonstrate that trans-dominant negative rev mutants are able to su ppress simian immunodeficiency virus provirus replication in both tran sient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated in a simian immunodeficiency vi rus-rhesus macaque animal model.