TRANSLOCATION T(8-13) IN A PATIENT WITH T-CELL LYMPHOMA AND FEATURES OF A MYELOPROLIFERATIVE SYNDROME

A 32-year-old white woman was admitted with a diagnosis of T lymphobla stic lymphoma and a bone marrow and peripheral blood cytology that was suggestive of a myeloproliferative syndrome (MPS). In addition, islet s of myeloid precursors were found in the lymph node where the lymphom a had been diagnosed. Cytogenetic examination was negative for the Phi ladelphia chromosome (Ph) as well as the RT-PCR for bcr/abl rearrangem ent, but surprisingly a t(8;13)(q10;p10) was detected. To our knowledg e, this translocation has not been reported in such a clinical setting . The patient was treated for the lymphoblastic lymphoma and underwent autologous bone marrow transplantation. She has been in complete remi ssion since induction chemotherapy with a Karnofsky score of 100%. The difficulty of classifying this case is discussed.