The pessimistic prognosis for cancerous diseases made by the founder o
f occidental medical science, Hippocrates of Cos (ca. 460 BC - ca. 370
BC), resulted also in the fact that the surgical treatment of breast
cancer was performed rather as a last resort. Not until the rise of sc
ientific surgery in the 16th century did European surgeons begin to de
velop different procedures in the surgical treatment of breast cancer.
In 1774, in a treatise rewarded by the Academy, the French surgeon Be
rnard Peyrilhe, who may be considered one of the founders of experimen
tal cancer research, demanded radical operative surgery in cases of br
east cancer. Peyrilhe first formulated the principles of that surgical
concept which is connected with the name of the American surgeon Will
iam Stewart Halsted (1852-1922), a concept which has long remained inf
luential.