CLONING AND SEQUENCING OF A CDNA-ENCODING A NOVEL MEMBER OF THE HUMANBRAIN GABA NORADRENALINE NEUROTRANSMITTER TRANSPORTER FAMILY/

Screening of a human hippocampal cDNA library with a rat creatine tran sporter cDNA-specific probe revealed two types of clones, One identica l to the published creatine transporter cDNA sequence (CRT1) and anoth er (CRT2) with four segments of oligodeoxyribonucleotide substitution or addition in different sites of the CRT1 coding sequence, Translatio n of the CRT2 coding sequence reveals a new protein with regions of pe rfect homology with the CRT1 amino-acid sequence.