GENES ENCODING HUMAN SERUM AMYLOID-A PROTEINS SAA1 AND SAA2 ARE LOCATED 18 KB APART IN OPPOSITE TRANSCRIPTIONAL ORIENTATIONS

Authors
KLUVEBECKERMAN B SONG M
Citation
B. Kluvebeckerman et M. Song, GENES ENCODING HUMAN SERUM AMYLOID-A PROTEINS SAA1 AND SAA2 ARE LOCATED 18 KB APART IN OPPOSITE TRANSCRIPTIONAL ORIENTATIONS, Gene, 159(2), 1995, pp. 289-290
Citations number
10
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
159
Issue
2
Year of publication
1995
Pages
289 - 290
Database
ISI
SICI code
0378-1119(1995)159:2<289:GEHSAP>2.0.ZU;2-N
Abstract
The three expressed genes of the human serum amyloid A gene family (SA A1, SAA2 and SAA4) have been isolated in four contiguous clones select ed from a chromosome 11 cosmid library. Analysis of these clones revea led that SAA1 and SAA2 are located 18 kb apart in opposite transcripti onal orientations: while SAA4 lies 11 kb downstream from SAA2 in the s ame orientation: 3'(SAA1)5'-18 kb-5'(SAA2)3'-11 kb-5'(SAA)3'. A fifth SAA clone isolated from this library was noncontiguous with the other four and contained the SAA3 pseudogene.