FUNCTIONAL AND PATHOPHYSIOLOGICAL MODELS OF THE BASAL GANGLIA

Because of new data, anatomical and functional models of the basal gan glia in normal and pathological conditions (e.g. Parkinson's and Hunti ngton's diseases) have recently come under greater scrutiny. An update of-these models is clearly timely, taking into consideration not only changes in neuronal discharge rates, but also changes in the patterni ng and synchronization of neuronal discharge, the role of extrastriata l dopamine, and expanded intrinsic and input/output connections of the se nuclei.