Recent work has demonstrated that the neural circuits mediating escape
reactions in lower vertebrates and mammals have a common framework, w
ith only two excitatory central synapses in the reflex are. This relat
ively direct linkage from sense organs to muscles and the fact that se
gments of the network also transmit other motor commands help guarante
e that escape always has priority over ongoing behaviors. Yet, modulat
ion and plasticity contribute some variability to the expression of es
cape and, therefore, to the adequacy of its survival function.