PEPTIDERGIC NEUROHORMONAL CONTROL-SYSTEMS IN INVERTEBRATES

Authors
Citation
Dr. Nassel, PEPTIDERGIC NEUROHORMONAL CONTROL-SYSTEMS IN INVERTEBRATES, Current opinion in neurobiology, 6(6), 1996, pp. 842-850
Citations number
69
Categorie Soggetti
Neurosciences
ISSN journal
09594388
Volume
6
Issue
6
Year of publication
1996
Pages
842 - 850
Database
ISI
SICI code
0959-4388(1996)6:6<842:PNCII>2.0.ZU;2-T
Abstract
The concerted activity of many neuropeptides has been implicated in th e neurohormonal control of specific behaviors and various physiologica l functions in some invertebrate model systems. What are the functiona l consequences of this neuropeptide multiplicity? The distinct actions of closely related neuropeptides have been detected in molluscs and i nsects; however, recent work provides examples of systems in which som e of the multiple isoforms may be functionally redundant, Groups of fu nctionally distinct neuropeptides encoded by the same gene can be expr essed in different neurons by alternative gene splicing or cell-specif ic post-translational processing; therefore, as shown recently, they c an be targeted for release as 'cocktails' to act on specific sets of m uscles or neurons. One prominent role of neuropeptides is to modulate the activity of rhythm-generating circuits, as exemplified by recent r esearch on mollusc neural networks, the crab stomatogastric ganglion, and fly circadian pacemakers.