Gb. Murzina et Ig. Silkis, THE CONTRASTING OF SYNAPTIC SIGNALS RESUL TING FROM SIMULTANEOUS MODIFICATIONS OF EXCITATORY AND INHIBITORY INPUTS, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 46(6), 1996, pp. 1076-1087
The participation of inhibition in the long-term contrasting of neural
interconnections was studied using the mathematical model of postteta
nic calcium-dependent postsynaptic processes in a CA3 hippocampal pyra
midal cell. It was demonstrated that if a presynaptic neuron fired dur
ing some time with a given frequency the modifiable inhibition selecti
vely promoted the long-term potentiation of the efficacy of excitatory
connection between the pre- and postsynaptic cells, while the efficac
y of other inputs to the same postsynaptic cell were depressed. The lo
ng-term depression of the efficacy of disynaptic inhibitory input unde
rlies such contrasting even in the case when the efficacy of the excit
atory input is low and weakly potentiated. Concerning other inputs, we
suppose that if the <<common>> inhibitory interneuron is simultaneous
ly activated by different presynaptic cells, the long-term heterosynap
tic potentiation of the inhibitory transmission will be induced. This
effect together with the unmodifiable excitatory heterosynaptic transm
ission will lead to the long-term depression of the excitatory connect
ions between various presynaptic cells and the given postsynaptic cell
.