Y. Kajimoto et al., DELAYED CHANGES IN NEURAL VISININ-LIKE CALCIUM-BINDING PROTEIN GENE-EXPRESSION CAUSED BY ACUTE PHENCYCLIDINE ADMINISTRATION, Journal of neural transmission, 100(3), 1995, pp. 257-262
Phencyclidine (PCP) induces a psychotomimetic state that closely resem
bles schizophrenia, and PCP-treated animals can serve as a model for s
chizophrenia. The effects of PCP on the gene expression of NVP-1, a no
vel Ca2+-binding protein, were studied in rats. After 24 hours, the NV
P-1 mRNA level in the nucleus accumbens showed a significant decrease
of 42%. This result suggests that alterations in Ca2+-binding protein
may be involved in the pathology of PCP-induced psychosis and, presuma
bly, schizophrenia.