INFLUENCE OF DIPHENIN, VALPROATE AND PENT OBARBITAL ON THE DEVELOPMENT OF EPILEPTIFORM SEIZURES IN KRUSHINSKY-MOLODKINA RATS

The anticonvulsant action of diphenin, sodium valproate, and pentobarb ital was studied in Krushinsky - Molodkina (KM) rats subjected to audi ogenic seizures. The anticonvulsant effects of the drugs were differen t and dose-dependent, Valproate in a dose of 120 mg/kg completely elim inated the tonic phase of seizures, Given in a dose of 300 mg/kg it in 50% of cases prevented from the development of the initial seizure st age of motor excitation. The peculiarity of the pentobarbital action c onsisted in its ability to change the character of motor excitation du ring sound stimulation from the one-wave reaction for the two-wave.