The sky rms is the simplest model-independent characterization of a co
smological anisotropy signal. We show that the rms temperature fluctua
tions determined from the COBE Differential Microwave Radiometer (DMR)
4 yr sky maps are frequency independent, consistent with the Planckia
n spectrum expected for the cosmic microwave background signal and the
refore with the hypothesis that they are cosmological in origin. The t
ypical rms amplitude is similar to 35 +/- 2 mu K at 7 degrees and simi
lar to 29 +/- 1 mu K at 10 degrees. An analysis of the rms anisotropy
determined from the data in both Galactic and ecliptic coordinates is
used to determine the rms quadrupole normalization, Q(rms-PS), for a s
cale-invariant Harrison-Zeldovich power-law model. Corrections are app
lied for small biases observed in the likelihood analysis. While there
are variations depending on the data selection, all results are consi
stent with a Q(rms-PS) normalization of similar to 18 +/- 2 mu K. This
is also shown to be true for a ''standard'' cold dark matter model of
cosmological anisotropy. The difference in the normalization amplitud
es derived when the quadrupole is either included or excluded from the
analysis is attributable to contamination of the observed sky quadrup
ole by foreground Galactic emission.