N,N-DIMETHYLBENZYLAMINE - OCCUPATIONAL EXPOSURE, ANALYSIS AND BIOLOGICAL MONITORING

Dimethylbenzylamine (DMBA) is used in the production of epoxy resins. The aims of this study were to assess occupational exposure to DMBA an d evaluate the usefulness of monitoring the urinary excretion of DMBA and DMBA metabolites as indicators of exposure to DMBA. A sensitive ga s chromatographic method for analysis of DMBA in air and in urine has been developed. The detection limit for DMBA in air for a 60-l air sam ple collected in 10 ml absorption solution was 2 mu g/m(3) and in char coal tubes, 0.3 mu g/m(3). The detection limit for DMBA in urine was 0 .02 mg/l. Ten male workers manufacturing epoxy resin were monitored du ring a full shift in the working environment and urine samples were co llected at the end of exposure. The mean exposure and the highest DMBA concentration observed in air were 18 mu g/m(3) (time-weighted averag e; range 3-48 mu g/m(3)) and 91 mu g/m(3), respectively. The DMBA conc entrations in the urine samples were below the detection limit. After reduction of the urine samples the DMBA concentrations (U-SumDMBA) ran ged from 0.02 to 0.22 mg/l. There was significant correlation between the exposure to DMBA and the U-SumDMBA. This observation suggests that the U-SumDMBA in urine samples collected at the end of a shift is a u seful indicator of occupational exposure to DMBA.