Issues related to the design of large systems are explored based on th
e axiomatic approach to design. A large system has the characteristic
of having to satisfy varying sets of functional requirements (FRs) ove
r its lifetime, some of which are not known a priori. Such a system mu
st therefore be designed to accommodate these varying and sometimes un
known sets of functional requirements. The design must also allow the
system to have an expandable database of design parameters (DPs) to sa
tisfy yet-unknown FRs and endow the system with ''intelligence'' to ma
ke correct decisions. The independence axiom and the information axiom
are the basis for several theorems that are derived for large systems
. These theorems characterize or establish the bounds on the large sys
tems. The implications of these theorems are examined using organizati
onal design and the design of intelligent manufacturing systems as exa
mples. Finally, the human cognitive process, including human creativit
y, is discussed as an example of a large system.