CENTRAL ADMINISTRATION OF CHOLECYSTOKININ STIMULATES GASTRIC PEPSINOGEN SECRETION FROM ANESTHETIZED RATS

Citation
C. Blandizzi et al., CENTRAL ADMINISTRATION OF CHOLECYSTOKININ STIMULATES GASTRIC PEPSINOGEN SECRETION FROM ANESTHETIZED RATS, Neuroscience letters, 193(1), 1995, pp. 13-16
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
193
Issue
1
Year of publication
1995
Pages
13 - 16
Database
ISI
SICI code
0304-3940(1995)193:1<13:CAOCSG>2.0.ZU;2-9
Abstract
Intracerebroventricular administration of CCK-8S was associated with a stimulation of gastric pepsinogen secretion from anaesthetized rats; similar effects were induced by CCK-8S given intravenously. The excita tory effect of intracerebroventricular CCK-8S was not modified by cent ral injection of L-364,718 or L-365,260, whereas both these antagonist s, given by intravenous route, prevented the pepsigogue action of pare nteral CCK-8S. Intracerebroventricular or intravenous CCK-8S also incr eased basal acid secretion, this latter effect being prevented by pare nteral L-365,260 but not L-364,718. It is suggested that centrally app lied CCK-8S evokes pepsinogen secretion through the activation of peri pheral CCK-A and CCK-B receptors.