C. Blandizzi et al., CENTRAL ADMINISTRATION OF CHOLECYSTOKININ STIMULATES GASTRIC PEPSINOGEN SECRETION FROM ANESTHETIZED RATS, Neuroscience letters, 193(1), 1995, pp. 13-16
Intracerebroventricular administration of CCK-8S was associated with a
stimulation of gastric pepsinogen secretion from anaesthetized rats;
similar effects were induced by CCK-8S given intravenously. The excita
tory effect of intracerebroventricular CCK-8S was not modified by cent
ral injection of L-364,718 or L-365,260, whereas both these antagonist
s, given by intravenous route, prevented the pepsigogue action of pare
nteral CCK-8S. Intracerebroventricular or intravenous CCK-8S also incr
eased basal acid secretion, this latter effect being prevented by pare
nteral L-365,260 but not L-364,718. It is suggested that centrally app
lied CCK-8S evokes pepsinogen secretion through the activation of peri
pheral CCK-A and CCK-B receptors.