O. Denk et al., ALLERGIC GRANULOMA OF THE CONJUNCTIVA (SP LENDORE-HOEPPLI-PHENOMENON), Klinische Monatsblatter fur Augenheilkunde, 206(6), 1995, pp. 478-479
A 35-year-old woman from Georgia presented with multiple bilateral yel
low nodules of the upper bulbar conjunctiva, accompanied by a severe i
njection of conjunctival vessels. The histologic examination of excisi
onal biopsies showed the characteristic morphology of the Splendore-Ho
eppli-phenomenon, which describes granulomas with a necrotized eosinop
hilic center, surrounded by a ring of epitheloid cells, giant cells an
d eosinophils. Although nematodes could be identified in only a few le
sions, they should always be kept in mind as the causing agent of this
condition. No cause of the lesions was found in our patient. The nodu
les may regress spontaneously. Topical application of corticosteroid e
ye drops, however, may give relief of symptoms, and sometimes excision
of the granulomas will be necessary.