A 32-yr-old man was admitted to Anjo Kosei Hospital for the examinatio
n of a cystic peritoneal lesion. This patient had a past medical histo
ry significant for an appendectomy. Ultrasonography and computed tomog
raphy revealed multiple cysts in the abdominal and pelvic cavities. An
exploratory laparotomy was performed on July 1, 1993, revealing numer
ous thin-walled and translucent cysts in the serosal tissues of the pa
rietal and visceral abdominal peritoneum. These cysts were excised sur
gically because of clinical suspicion of pseudo-myxoma peritonei, Micr
oscopic examination revealed cysts within the thin cyst wall that were
composed of fibrous connective tissue and lined by a single layer of
cuboidal or flattened epithelium. Immunohistochemical and ultrastructu
ral studies demonstrated that the lining cells were of mesothelial ori
gin, and the diagnosis was benign cystic mesothelioma. In this paper,
we present appropriate diagnostic and treatment procedures for benign
cystic mesothelioma and discuss the particular usefulness of using imm
unohistochemical methods to achieve a histological diagnosis.