DIFFUSE PULMONARY-INFILTRATES AND WALDENS TROM DISEASE

The case of an 52 years old female presenting dyspnea and pulmonary in filtration is reported. A transbronchial biopsy showing a lymphomatous infiltrate with immunohistochemistry using anti-IgM antibody on paraf fine embedded section helped to diagnose. A monoclonal increase in ser ic immunoglobin M, led to the diagnosis of Waldrenstrom's macroglobuli nemia. An initial therapeutic response to Chlorambucil was obtained. B ut a quick recurrence was observed, with an increase of seric IgG.