Trigeminal neuralgia (TN) occurred in 35 patients (1.9%) from a large
multiple sclerosis (MS) clinic population (N = 1,882). TN began on ave
rage 11.8 years after the first MS symptom but in five patients was th
e first. symptom of MS, preceding the next MS symptom by 1 to 11 years
. The onset of MS was later in the patients who had TN, and bilateral
TN occurred more frequently than expected (in 14% of TN patients). The
age at onset of TN was no younger than in idiopathic TN except when T
N was the first MS symptom. Most patients had a good result from medic
al or surgical therapy.