SELECTIVE EFFECT OF 2-(POLYHYDROXYALKYL)-THIAZOLIDINE-4-CARBOXYLIC ACIDS ON NONPROTEIN SULFHYDRYL-GROUPS IN TUMOR-BEARING MICE

1. Thiazolidine derivatives (TD), the products of condensation of L-cy steine (cys) with sugars (D-glucose, D-xylose, D-arabinose, D-galactos e, and D-mannose), successfully elevated nonprotein sulfhydryl (NPSH) levels in livers of Ehrlich ascites tumor (EAT)-bearing mice. 2. At th e same time, TD promoted a significant drop of NPSH in EAT cells. 3. T hus, TD, through their selective influence on the levels of NPSH in li ver and cancer cells appear to be promising compounds for anticancer t herapy. Copyright (C) 1996 Elsevier Science Inc.