EVALUATION OF THE ANTIINFLAMMATORY ACTIVITY OF SODIUM VALPROATE IN RATS AND MICE

1. Treatment of rats with sodium valproate (100, 200 and 400 mg/kg IF) reduced the paw oedema induced by carrageenan by 36, 15 and 48%, resp ectively, within 3 h. 2. The effect produced by the higher dose (400 m g/kg) was equivalent to that produced by indomethacin (100 mg/kg), At 100 and 400 mg/kg, sodium valproate decreased the granuloma formation by a significant level. Similar doses of sodium valproate did not affe ct the rectal temperature in yeast-fevered mice, except with a dose of 200 mg/kg, which showed a significant decrease at 180 and 240 min pos ttreatment. 3. In comparison, sodium salicylate reduced the hypertherm ia very significantly throughout the study period. 4. In normothermic mice, the rectal temperature changed only with a 400 mg/kg dose, but d id not respond to lower SV doses. 5. The results indicate that sodium valproate, useful clinically as an epileptic drug, may have a potentia l therapeutic use as a mild antiinflammatory agent. Copyright (C) 1996 Elsevier Science Inc.