ANALYSIS OF A 2(9) FULL FACTORIAL CHEMICAL LIBRARY

Robotic synthesis is making possible the synthesis of large, systemati cally designed sets of compounds. We analyze a 512-compound set that i s a 2(9) full factorial experimental design using a recursive partitio ning algorithm, FIRM, and a high-dimension visualization tool, TempleM VV. These techniques are used to quickly and easily identify the main trends in the data set and also identify unusual observations. We show that analytical and visualization methods can be used synergistically to analyze a large, complex, high-dimensional data set. We also show that a fractional factorial design of 128 compounds would give essenti ally the sane information.