HIV-POSITIVE PATIENTS FIRST PRESENTING WITH AN AIDS-DEFINING ILLNESS - CHARACTERISTICS AND SURVIVAL

Objectives-To study the presentation and survival of patients who pres ent with their first diagnosis of being HIV positive at the same time as their AIDS defining illness. Design-Retrospective study of patients presenting with AIDS between 1991 and 1993. Setting-Department of gen itourinary medicine, St Mary's Hospital, London. Main outcome measures -AIDS defining illness at presentation and survival after diagnosis of AIDS. Results-Between January 1991 and December 1993, 97 out of 436 p atients (22%) presented with their first AIDS defining illness coincid ent with their first positive result of an HIV test (group B). The rem aining 339 patients (78%) had tested positive for, HIV-1 infection wit hin the previous eight years and had consequently been followed up in clinics before developing their first AIDS defining illness (group A). The two groups of patients did not differ in age and sex distribution , risk factors for HIV-1 infection, nationality, country of origin, or haematological variables determined at the time of the AIDS defining illness. However, the defining illnesses differed between the two grou ps. Illnesses associated with severe immunodeficiency (the wasting syn drome, cryptosporidiosis, and cytomegalovirus infection) were seen alm ost exclusively in group A whereas extrapulmonary tuberculosis and Pne umocystis carinii pneumonia were more common in group B. The survival of patients in group B after the onset of AIDS was significantly longe r than that of patients in group A as determined by Kaplan-Meier log r ank analysis (P = 0.0026). Conclusions-Subjects who are HIV positive a nd present late are a challenge to the control of the spread of HIV in fection because they progress from asymptomatic HIV infection to AIDS without receiving health care. The finding that presentation with an A IDS defining illness coincident with a positive result in an HIV test did not have a detrimental effect on survival gives insights into the effects of medical intervention on disease progression after a diagnos is of AIDS.