Endoscopes for use in ophthalmology can now be manufactured with overa
ll intraocular diameters smaller than 0.89 mm. Endoscopes based on gra
dient-index lenses yield a higher resolution than those making use of
ordered fiber bundles having the same diameter. Likewise, endoscopes w
ith optical elements having a diameter of 0.50 mm yield a higher resol
ution than those with smaller diameter (0.35 mm). Thanks to the miniat
urization, a working channel can also be integrated within the tube of
the endoscope instead of being a part of the illumination bundle. Thi
s allows the design of new endoscopic devices including various surgic
al instruments. Preference is given to an endoscope with an integrated
aspiration/irrigation system or with a fiber for laser therapy. The p
otential phototoxicity of these systems is briefly discussed.