STRUCTURAL ABNORMALITIES OF CHROMOSOME 7Q IN CHRONIC LYMPHOPROLIFERATIVE DISORDERS

Structural abnormalities of 7q are common in myeloid malignancies but rarely reported in chronic lymphoproliferative disorders. 7q abnormali ties were found in 29 of 796 patients (3.6%) with chronic lymphoid mal ignancies. The most common association was found in splenic lymphoma w ith villous lymphocytes (SLVL) in which 8 of 31 cases (26%) has one or more abnormalities of 7q. The most common abnormalities were deletion s involving 7q32 and deletions or translocation of 7q22. There was no correlation between the type of lymphoid disorder or clinical course a nd specific structural abnormalities. We postulate that genes importan t in the pathogenesis of SLVL may reside on 7q22 and/or 7q32. (C) Else vier Science Inc., 1996