THE ETS FAMILY OF PROTEINS - WEAK MODULATORS OF GENE-EXPRESSION IN QUEST FOR TRANSCRIPTIONAL PARTNERS

Authors
CREPIEUX P COLL J STEHELIN D
Citation
P. Crepieux et al., THE ETS FAMILY OF PROTEINS - WEAK MODULATORS OF GENE-EXPRESSION IN QUEST FOR TRANSCRIPTIONAL PARTNERS, Critical reviews in oncogenesis, 5(6), 1994, pp. 615-638
Citations number
192
Categorie Soggetti
Oncology
Journal title
Critical reviews in oncogenesis → ACNP
ISSN journal
08939675
Volume
5
Issue
6
Year of publication
1994
Pages
615 - 638
Database
ISI
SICI code
0893-9675(1994)5:6<615:TEFOP->2.0.ZU;2-S
Abstract
Members of the Ets family of transcriptional regulators play pivotal r oles in physiological processes, such as embryonic development or immu ne response. The Ets family proteins possess unique regulatory feature s because they bind DNA as monomers and their respective activities re ly more on their ability to interact with other transcription factors than on their specific binding to a cognate DNA sequence. This review focuses on such interactions and also explores dysregulated expression of the Ets proteins in human cancers.