CLONING AND EXPRESSION OF 2 BRAIN-SPECIFIC INWARDLY RECTIFYING POTASSIUM CHANNELS

Authors
BREDT DS WANG TL COHEN NA GUGGINO WB SNYDER SH
Citation
Ds. Bredt et al., CLONING AND EXPRESSION OF 2 BRAIN-SPECIFIC INWARDLY RECTIFYING POTASSIUM CHANNELS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(15), 1995, pp. 6753-6757
Citations number
36
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
92
Issue
15
Year of publication
1995
Pages
6753 - 6757
Database
ISI
SICI code
0027-8424(1995)92:15<6753:CAEO2B>2.0.ZU;2-W
Abstract
We have cloned two inwardly rectifying K+ channels that occur selectiv ely in neurons in the brain and are designated BIRK (brain inwardly re ctifying K+) channels. BIRK1 mRNA is extremely abundant and is enriche d in specific brainstem nuclei, BIRK1 displays a consensus phosphate-b inding loop, and expression in Xenopus oocytes has shown that its cond uctance is inhibited by ATP and adenosine 5'-[gamma-thio] triphosphate . BIRK2 is far less abundant and is selectively localized in telenceph alic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosph orylation.