INACTIVATION OF SIMIAN IMMUNODEFICIENCY VIRUS BY HYDROSTATIC-PRESSURE

The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of i nactivation depended on the time that the virus was subjected to compr ession as well as the level of the pressure and at 150 Mpa reached 5 l og(10) dilution units after approximate to 10 hr. The inactivations, w hich were uniformly carried out at room temperature, were independent of the concentration of the virus. Possible applications of pressure i nactivation for molecular biological and clinical use are discussed.