THE SYNTHESIS AND PROPERTIES OF N-(BETA-T RIPHENYLGERMANYL) PROPIONYL-ALPHA-AMINO-METHYLPHOSPHONATES

Authors
CHEN RY MAO LJ
Citation
Ry. Chen et Lj. Mao, THE SYNTHESIS AND PROPERTIES OF N-(BETA-T RIPHENYLGERMANYL) PROPIONYL-ALPHA-AMINO-METHYLPHOSPHONATES, Gaodeng xuexiao huaxue xuebao, 16(6), 1995, pp. 892-895
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
16
Issue
6
Year of publication
1995
Pages
892 - 895
Database
ISI
SICI code
0251-0790(1995)16:6<892:TSAPON>2.0.ZU;2-T
Abstract
In this paper, two series of N-(beta-triphenylgermanyl) propionyl-alph a-amino-methylphosphonates have been synthesized and both conditions a nd mechanism of the condensation reaction of sterically hindered alpha -aminomethylphosphonate with beta-triphenylgermanyl propionic acid wer e studied. Preliminary bioassays indicate that the title compounds com pared with corresponding alpha-amino-methylphosphonates have more sign ificant antitumor and anti-TMV properties.