URINARY PH AND UREA CONCENTRATION CORRELATE TO THE BACTERIAL-COLONIZATION RATE IN GASTRIC, COLONIC, ILEAL AND MYOPERITONEAL BLADDER AUGMENTATION

We investigated how various types of augmentation cystoplasty alter th e native bacteriostatic properties of urine, particularly urinary urea and pH, in the Sprague-Dawley rat. The augmentation cystoplasties stu died included 1 cm.(2) and 2 cm.(2) patches of colon, ileum and stomac h as well as myoperitoneal bladder flaps. Augmentations in order of de creasing incidence of bacteriuria and urinary pH are 2 cm.(2) ileal gr eater than 1 cm.(2) ileal greater than 2 cm.(2) colonic greater than 1 cm.(2) colonic greater than myoperitoneal greater than cystotomy alon e greater than 1 cm.(2) gastric greater than 2 cm.(2) gastric. Urinary urea concentrations were similar between cystotomy alone, and myoperi toneal and gastric augments. In contrast, all colonic and ileal augmen ts had significantly lower urea concentrations compared to the aforeme ntioned groups. Our findings suggest that the type and size of augment ation directly affect urinary pH and urea nitrogen concentration, and the incidence of bacteriuria.