C. Fortis et al., SERUM LEVELS OF SOLUBLE CELL-ADHESION MOLECULES (ICAM-1, VCAM-1, E-SELECTIN) AND OF CYTOKINE TNF-ALPHA INCREASE DURING INTERLEUKIN-2 THERAPY, Clinical immunology and immunopathology, 76(2), 1995, pp. 142-147
Circulating levels of soluble intracellular adhesion molecule-1, vascu
lar cell adhesion molecule-1, and E-selectin mere measured in 20 advan
ced cancer patients at different times during recombinant interleukin-
a immunotherapy. The concentration of all three molecules progressivel
y increased as did the levels of circulating tumor necrosis factor-alp
ha (TNF-alpha), which is known to induce endothelial cell activation.
A fair direct relationship (but not statistically significant) between
the raised concentration of soluble cell adhesion molecules and TNF-a
lpha was observed. We suggest that elevated levels of soluble adhesion
molecules and TNF-alpha in the blood of IL-a-treated patients may ari
se from a systemic inflammatory reaction producing endothelial cell ac
tivation. (C) 1995 Academic Press, Inc.