POLYCYSTIC OVARIAN SYNDROME - PREGNANCY OUTCOME FOLLOWING IN-VITRO FERTILIZATION-EMBRYO TRANSFER

A retrospective study of a series of pregnant patients with polycystic ovarian syndrome following in vitro fertilization-embryo transfer was conducted to assess the outcome after ovarian stimulation by differen t protocols. Forty-one pregnancies were evaluated in patients with pol ycystic ovarian syndrome who conceived during in vitro fertilization-e mbryo transfer using human menopausal gonadotropin alone (17 pregnanci es), or combined with gonadotropin releasing hormone analog (24 pregna ncies). The demographic data of in vitro fertilization-embryo transfer cycles and pregnancy outcome were compared with the use of Student's t-test, the Mann-Whitney U test and Fisher's exact test, where appropr iate. Among the pregnancies that were initiated following treatment, t he protocol of the combination of the two was not associated with a hi gher rate of deliveries. The rate of first-trimester abortions was not statistically different between the two groups. These results suggest that the combined use of gonadotropin releasing hormone agonist and h uman menopausal gonadotropin in an in vitro fertilization program may not have beneficial effects on pregnancy outcome in patients with poly cystic ovarian syndrome.