Hepatitis is a well-recognised complication of Epstein-Barr virus (EBV
) infection that usually resolves spontaneously. Jaundice occasionally
results from the unusual complication of autoimmune haemolytic anaemi
a rather than hepatitis. Two adult patients are described with infecti
ous mononucleosis-related hepatitis who also developed significant hae
molysis, a situation that could have led to diagnostic delay and a del
eterious outcome. Haemolysis should be considered in all patients who
become jaundiced after infectious mononucleosis. The management of thi
s potentially fatal complication is discussed.