SYNTHESIS OF OMETHYL)PHOSPHINYL]METHYL)-ALPHA-D-GALACTOFURANOSE - A ZARAGOZIC ACID - PRESQUALENE PYROPHOSPHATE HYBRID

Authors
VALENTIJN ARPM BROXTERMAN HJG VANDERMAREL GA COHEN LH VANBOOM JH
Citation
Arpm. Valentijn et al., SYNTHESIS OF OMETHYL)PHOSPHINYL]METHYL)-ALPHA-D-GALACTOFURANOSE - A ZARAGOZIC ACID - PRESQUALENE PYROPHOSPHATE HYBRID, Journal of carbohydrate chemistry, 14(6), 1995, pp. 737-749
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Journal of carbohydrate chemistry → ACNP
ISSN journal
07328303
Volume
14
Issue
6
Year of publication
1995
Pages
737 - 749
Database
ISI
SICI code
0732-8303(1995)14:6<737:SOO-AZ>2.0.ZU;2-E
Abstract
A multi-step synthesis of a new potential inhibitor (i.e., compound 2) of squalene synthase is described, starting from D-galactose. The tit le compound is a hybrid of presqualene pyrophopshate and the recently discovered zaragozic acids, which are picomolar competitive inhibitors of the enzyme squalene synthase.