Objectives: To review the current literature pertaining to the cardiov
ascular adaptations to exercise and the impact on the physical examina
tion: the electrocardiogram, and the echocardiogram, and to distinguis
h those physiologic changes from pathologic conditions associated with
sudden cardiac death in athletes. Data Synthesis: Specific cardiovasc
ular adaptations occur in response to regular physical exercise. The e
xtent of these changes depend on the type and duration of exercise as
well as the gender of the athlete. These cardiac adaptations are morph
ologically different from those conditions associated with sudden card
iac death. In the athlete younger than 35 years, hypertrophic cardiomy
opathy is the most common cardiac condition associated with sudden dea
th. Right ventricular dysplasia, idiopathic left ventricular hypertrop
hy, coronary anomalies, premature atherosclerosis, and Marfan syndrome
compose the majority of the remaining causes of sudden cardiac death
in athletes. In the athlete older than 35 years, coronary atherosclero
sis is the leading cause of sudden death followed by those conditions
responsible for sudden death in the younger athlete. Despite this, reg
ular exercise before or following a myocardial infarction provides a p
rotective effect with respect to overall mortality, cardiovascular mor
tality, and fatal reinfarction rates. Conclusions: Cardiovascular adap
tation to regular physical exercise leads to morphologic changes in th
e myocardium that influence the cardiac examination, the electrocardio
gram, and the echocardiogram. Knowledge and recognition of those chang
es can allow the clinician to distinguish normal physiologic changes f
rom cardiac abnormality. Proper detection of athletes at high risk for
sudden cardiac death and abstention from vigorous physical activity i
n these athletes may prevent sudden death.