We examined 535 central venous catheterizations performed in a neonata
l intensive care unit. A total of 273 catheters were positioned using
intra-atrial ECG monitoring. With an average indwelling time of 23 day
s, we noted one complication for every 153 indwelling catheter days. A
diagnosis of sepsis was confirmed on 22 occasions (4.1%). Sepsis occu
rred more often in infants with a birth weight < 1000 g (6.9%) compare
d with infants > 1000 g (3.1%). The risk of phlebitis was highest when
the saphenous vein was used as the puncture site. The lowest risk of
phlebitis was when the basilic vein was chosen. Five cases of thrombos
is, two of myocardial perforation and one intravascular catheter break
age were registered. Catheter placement under ECG monitoring proved to
be a very suitable method for reducing the incidence of malpositionin
g. There were no side effects specific to the ECG method. The ECG meth
od can be used safely and makes radiological control usually unnecessa
ry.