FAILURE OF CEFOTAXIME TREATMENT IN 2 CHILDREN WITH MENINGITIS CAUSED BY HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE

Authors
GUIBERT M CHAHIME H PETIT J ODIEVRE M LABRUNE P
Citation
M. Guibert et al., FAILURE OF CEFOTAXIME TREATMENT IN 2 CHILDREN WITH MENINGITIS CAUSED BY HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE, Acta paediatrica, 84(7), 1995, pp. 831-833
Citations number
11
Categorie Soggetti
Pediatrics
Journal title
Acta paediatrica → ACNP
ISSN journal
08035253
Volume
84
Issue
7
Year of publication
1995
Pages
831 - 833
Database
ISI
SICI code
0803-5253(1995)84:7<831:FOCTI2>2.0.ZU;2-F
Abstract
Two infants, aged 8.5 and 11 months, were admitted for meningitis caus ed by Streptococcus pneumoniae. Failure of cefotaxime led to the ident ification of highly penicillin-G-resistant strains. Minimum inhibitory concentrations (MICs) for penicillin were > 2 mu g/ml, and cefotaxime MICs were 2 mu g/ml. Both patients rapidly responded to a combination of iv imipenem and rifampicin. It is now mandatory to test in-vitro s usceptibilities of Streptococcus pneumoniae to penicillin G and other beta-lactam agents when meningitis is diagnosed in infants.