DNA-ADDUCTS CAUSED BY TAMOXIFEN AND TOREMIFENE IN HUMAN MICROSOMAL SYSTEM AND LYMPHOCYTES IN-VITRO

Authors
HEMMINKI K WIDLAK P HOU SM
Citation
K. Hemminki et al., DNA-ADDUCTS CAUSED BY TAMOXIFEN AND TOREMIFENE IN HUMAN MICROSOMAL SYSTEM AND LYMPHOCYTES IN-VITRO, Carcinogenesis, 16(7), 1995, pp. 1661-1664
Citations number
20
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
16
Issue
7
Year of publication
1995
Pages
1661 - 1664
Database
ISI
SICI code
0143-3334(1995)16:7<1661:DCBTAT>2.0.ZU;2-Y
Abstract
DNA-binding of tamoxifen and toremifene was studied in rat in vivo, in human and rat microsomes in vitro, and in cultured primary human lymp hocytes by P-32-postlabelling. Only tamoxifen caused DNA adducts in ra t liver. Both compounds induced adducts in both rat and human microsom al systems and in cultured lymphocytes. The levels of adducts in micro somes and lymphocytes were low, ca. 1 adduct/10(9) nucleotides. Toremi fene showed lower binding in each system, and in lymhocytes adducts we re only detected at a cytotoxic dose level.