Jf. Thompson et al., SENTINEL LYMPH-NODE STATUS AS AN INDICATOR OF THE PRESENCE OF METASTATIC MELANOMA IN REGIONAL LYMPH-NODES, Melanoma research, 5(4), 1995, pp. 255-260
The value of elective lymph node dissection (ELND) for melanoma patien
ts with clinically uninvolved regional nodes remains controversial, Ho
wever, it has been proposed that selective 'sentinel' lymph node biops
y reliably identifies individuals with micrometastases, who are most l
ikely to benefit from full ELND, The aim of this study was to confirm
that metastatic melanoma cells travelling in lymphatics do not bypass
the sentinel node. After preoperative lymphoscintigraphy and intraoper
ative injection of blue dye around the primary melanoma site, sentinel
node biopsy was performed in 118 melanoma patients for whom full ELND
was planned as part of their definitive surgical treatment, A confide
ntly identified sentinel node was tumour positive in 22 out of 105 reg
ional lymph node fields (21%). In 18 cases the sentinel node was the o
nly node found to be involved and in four cases, additional nodes were
positive. In two other patients a positive node was found when the se
ntinel lymph node had been negative. However, in each case an avoidabl
e error of technique had occurred and definite blue staining indicated
that the positive node was in fact another sentinel node. This study
thus confirms that sentinel lymph node status reliably indicates wheth
er metastatic melanoma is present in regional lymph nodes.