OROSOMUCOID PHENOTYPING WITH MONOCLONAL-ANTIBODIES - POLYMORPHIC OCCURRENCE OF ORM1-ASTERISK-QO IN ABORIGINAL TAIWANESE POPULATIONS

Authors
UMETSU K YUASA I HARADA A SUZUKI T PAN IH ISHIDA T SAITOU N HORAI S
Citation
K. Umetsu et al., OROSOMUCOID PHENOTYPING WITH MONOCLONAL-ANTIBODIES - POLYMORPHIC OCCURRENCE OF ORM1-ASTERISK-QO IN ABORIGINAL TAIWANESE POPULATIONS, Human heredity, 45(4), 1995, pp. 181-185
Citations number
16
Categorie Soggetti
Genetics & Heredity
Journal title
Human heredity → ACNP
ISSN journal
00015652
Volume
45
Issue
4
Year of publication
1995
Pages
181 - 185
Database
ISI
SICI code
0001-5652(1995)45:4<181:OPWM-P>2.0.ZU;2-O
Abstract
Three monoclonal antibodies (OR35, OR40 and OR48) against orosomucoid (ORM) were prepared for the phenotyping of the human ORM system. The O R35 and OR48 antibodies recognized ORM1 and ORM2 products, respectivel y. OR40 reacted strongly to the products of ORM1 but poorly to those o f ORM2. With the help of these monoclonal antibodies, ORM phenotyping was performed on 658 individuals from nine subpopulations of aborigina l Taiwanese, with close attention to two individuals with an ORM1 Q0 h omozygous phenotype. The ORM1()Q0 allele was found to be at a polymor phic frequency in eight of the nine subpopulations.