K. Umetsu et al., OROSOMUCOID PHENOTYPING WITH MONOCLONAL-ANTIBODIES - POLYMORPHIC OCCURRENCE OF ORM1-ASTERISK-QO IN ABORIGINAL TAIWANESE POPULATIONS, Human heredity, 45(4), 1995, pp. 181-185
Three monoclonal antibodies (OR35, OR40 and OR48) against orosomucoid
(ORM) were prepared for the phenotyping of the human ORM system. The O
R35 and OR48 antibodies recognized ORM1 and ORM2 products, respectivel
y. OR40 reacted strongly to the products of ORM1 but poorly to those o
f ORM2. With the help of these monoclonal antibodies, ORM phenotyping
was performed on 658 individuals from nine subpopulations of aborigina
l Taiwanese, with close attention to two individuals with an ORM1 Q0 h
omozygous phenotype. The ORM1()Q0 allele was found to be at a polymor
phic frequency in eight of the nine subpopulations.