CD11A CD18 AND CD11B/CD18 MODULATION BY LIPOTEICHOIC ACID, N-ACETYL-MURAMYL-ALPHA-ALANYL-D-ISOGLUTAMINE, MURAMIC ACID AND PROTEIN-A FROM STAPHYLOCOCCUS-AUREUS/

This study investigates the effect of some components of the Staphyloc occus aureus cell wall [lipoteichoic acid (LTA), M-acetyl-muramyl-alan yl-D-isoglutamine (MD), muramic acid (MA) and protein A (PA)] in modul ating expression of cell-surface adhesion molecules CD11a/CD18, CD11b/ CD18 on monocytes qualitatively and quantitatively. Monocytes incubate d with bacterial components presented different CD11b/CD18 expressions which were dose-dependent in contrast to controls. The results obtain ed demonstrated that lymphocytes incubated with bacterial components a lso increased the expression of CD11a/CD18. The modifications in activ ation of CD11a/CD18 and CD11b/CD18 expression are probably correlated with modifications of membrane fluidity measured as polarisation fluor escence (P).