Cr. Cloninger et al., PERSONALITY ANTECEDENTS OF ALCOHOLISM IN A NATIONAL AREA PROBABILITY SAMPLE, European archives of psychiatry and clinical neuroscience, 245(4-5), 1995, pp. 239-244
Kraepelin viewed alcoholism as a symptom complex caused by heritable i
ndividual differences in emotional predisposition and volitional contr
ol. Recent clinical and genetic research has distinguished subtypes of
alcoholics with different personality traits, symptoms, course, mode
of inheritance, and response to treatment. The heritable personality t
raits that influence the initiation, continuation, and severity of alc
oholism were examined by interview of a national area probability samp
le of 1019 non-institutionalized adults across the continental United
States of America. We found that harm avoidance inhibits the initiatio
n and frequency of drinking, but increases the risk of developing prob
lems once frequent drinking has begun. Novelty seeking increases the i
nitiation of drinking and the probabilities of frequent and problem dr
inking. This supports Kraepelin's description of the etiology and cour
se of alcoholism as a symptom complex related to individual difference
s in emotional predisposition.