Aims-The risk of developing cataract in patients with untreated glauco
ma or with ocular hypertension was evaluated by comparing the values o
f lenticular autofluorescence and light transmission in 16 patients wi
th primary open angle glaucoma and 22 patients with ocular hypertensio
n with those of 24 healthy controls. Methods-Increase of lenticular au
tofluorescence and decrease of transmission values in comparison with
controls were considered to be precursors of cataract. The values of b
oth variables were determined by fluorophotometry. Each value was norm
alised for age by dividing it by the value for a healthy control of th
e same age. Results-The mean age normalised autofluorescence and trans
mission values of all patients did not differ significantly from those
of the controls (difference <5%; p=0.6 and p=0.2, respectively). Also
the mean age normalised autofluorescence and transmission values betw
een glaucoma and ocular hypertension patients did not differ significa
ntly (p=0.8 and p=0.9, respectively). Conclusion-The study indicates t
hat untreated primary open angle glaucoma or untreated ocular hyperten
sion do not seem to increase significantly the risk of developing cata
ract.