POTENTIAL CARCINOGENICITY OF THE SYNTHETIC 1,3,6-TRIAZINE (6-AZA) NUCLEIC-ACID ANALOGS DETERMINED BY DC POLAROGRAPHY .1. NUCLEOBASES

Authors
NOVOTNY L VACHALKOVA A PISKALA A PETRASOVA R BLESOVA B
Citation
L. Novotny et al., POTENTIAL CARCINOGENICITY OF THE SYNTHETIC 1,3,6-TRIAZINE (6-AZA) NUCLEIC-ACID ANALOGS DETERMINED BY DC POLAROGRAPHY .1. NUCLEOBASES, Neoplasma, 43(6), 1996, pp. 403-406
Citations number
15
Categorie Soggetti
Oncology
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
43
Issue
6
Year of publication
1996
Pages
403 - 406
Database
ISI
SICI code
0028-2685(1996)43:6<403:PCOTS1>2.0.ZU;2-8
Abstract
The polarographic reduction of Several synthetic 1,3,6-triazine (6-aza ) nucleobases in the strictly anhydrous solution was studied in the ab sence and presence of alpha-lipoic acid. The values of the half-wave p otentials E(1/2) and the parameter of potential carcinogenicity tg alp ha were determined for one natural and 5 synthetic nucleobases. The cu rrent value of the first diffuse polarographic wave or a new diffuse p olarographic wave belonging to the nucleobase-alpha-lipoic acid comple x increased with the increased alpha-lipoic acid concentration for the all compounds only marginally. Although this diffuse current increase was linearly depended on the alpha-lipoic acid concentration in anhyd rous solutions, the determined index tg alpha values ranging between 0 .029 and 0.108 indicated a very low potential carcinogenicity of the a ll nucleobases investigated.