Jt. Kuikka et al., I-123 LABELED -BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)NORTROPANE FOR DOPAMINE TRANSPORTER IMAGING IN THE LIVING HUMAN BRAIN, European journal of nuclear medicine, 22(7), 1995, pp. 682-686
There are several cocaine analogs which have potential for imaging the
dopamine transporters (DAT). Earlier studies have shown that iodine-1
23 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([I-123]b
eta-CIT) and N-(3-fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-iodophen
yl)nortropane ([I-123]P-CIT-FP) are promising DAT imaging agents in th
e living human brain with single-photon emission tomography (SPET). He
re we report a pilot comparison of [I-123]beta-CIT and [I-123]beta-CIT
-FP with a new tropane derivative, [I-123]N-(2-fluoroethyl)-2 beta-car
bomethoxy-3 beta-(4-iodophenyl)nortropane ([I-123]beta-CIT-FE), using
SPET imaging in four healthy male subjects. Peak uptake of [I-123]beta
-CIT-FE into the basal ganglia occurred very rapidly (0.5 h after inje
ction of tracer), after which the striatal washout obeyed a bi-exponen
tial form. The specific DAT binding of [I-123]beta-CIT-FE into the bas
al ganglia was somewhat less (0.785 +/- 0.117) than that of [I-123]bet
a-CIT (0.922 +/- 0.004) or [I-123]beta-CIT-FP (0.813 +/- 0.047). All t
hese tracers have excellent imaging quality in healthy control subject
s. However, the relatively fast washout of [I-123]beta-CIT-FE and low
temporal resolution of older SPET cameras may limit the use of this tr
acer to the measurement of the DAT density.