Cm. Villalon et al., 5-HYDROXYTRYPTAMINE INHIBITS PRESSOR-RESPONSES TO PREGANGLIONIC SYMPATHETIC-NERVE STIMULATION IN PITHED RATS, Life sciences, 57(8), 1995, pp. 803-812
Citations number
25
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
5-Hydroxytryptamine (5-HT) inhibits contractile responses to adrenergi
c nerve stimulation in several blood vessels and organs. We have now i
nvestigated the potential ability of 5-HT to inhibit the presser respo
nses caused by preganglionic sympathetic stimulation (T-7-T-9) in pith
ed rats. Sympathetic stimulation (0.03, 0.1, 0.3, 1 and 3 Hz) resulted
in frequency-dependent increases in diastolic blood pressure; these e
ffects were augmented after i.v. treatment with desipramine (50 mu g/k
g). During continuous infusions of 5-HT (1.8, 3.1, 5.6 and 10 mu g/kg.
min, i.v.), but not of saline, the presser responses were dose-depende
ntly inhibited in both control and desipramine-pretreated rats; this i
nhibitory effect of 5-HT was significantly more pronounced at lower fr
equencies of stimulation. In contrast, the above infusions of 5-HT did
not inhibit the presser responses induced by i.v. bolus injections of
exogenous norepinephrine (up to 3 mu g/kg). Taken together, the above
findings suggest an operative 5-HT-induced prejunctional inhibition o
f sympathetic nerve activity on the systemic vasculature in vivo.