DO ELEVATED CONCENTRATIONS OF SERUM PARAT HYROID-HORMONE LEAD TO LOWER BLOOD-PRESSURE VALUES IN PATIENTS ON LONG-TERM HEMODIALYSIS

In patients on longterm hemodialysis therapy with secondary hyperparat hyroidism the relation between parathyroid hormone and blood pressure is not clear. In 100 unselected longterm hemodialysis patients serum c oncentrations of parathyroid hormone (PTH, 1-84) were correlated after classification into a normotensive (n = 41), a hypotensive (n = 22) a nd a hypertensive group (n = 37). Serum PTH concentrations were signif icantly higher in the hypotensive group (57.0 +/- 59.3) as compared to the normotensive (18.0 +/- 25.8) or the hypertensive (18.6 +/- 26.5 p mol/l) group. The patients in the hypertensive group had been on hemod ialysis therapy for a shorter period of time (43.2 +/- 52.1) than the normotensive (71.4 +/- 57.7) or the hypotensive group (83.5 +/- 52.6 m onths). Serum concentrations of calcium and inorganic phosphate and ag e were not significantly different between the 3 groups. Our study sho ws that elevated serum PTH concentration can be associated with low ar terial blood pressure in patients on longterm hemodialysis.