A 2-STEP CHEMICAL AND CIRCULAR DICHROIC METHOD FOR ASSIGNING THE ABSOLUTE-CONFIGURATIONS OF SPHINGOSINES

Authors
DIRSCH V FREDERICO J ZHAO N CAI GL CHEN YQ VUNNAM S ODINGO J PU H NAKANISHI K BEROVA N LIOTTA D BIELAWSKA A HANNUN Y
Citation
V. Dirsch et al., A 2-STEP CHEMICAL AND CIRCULAR DICHROIC METHOD FOR ASSIGNING THE ABSOLUTE-CONFIGURATIONS OF SPHINGOSINES, Tetrahedron letters, 36(28), 1995, pp. 4959-4962
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
28
Year of publication
1995
Pages
4959 - 4962
Database
ISI
SICI code
0040-4039(1995)36:28<4959:A2CACD>2.0.ZU;2-4
Abstract
Breakdown products of sphingolipids are involved in cell regulation an d exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two ste reogenic centers. A general, rapid, chemical/chiroptical micromethod b ased on the bichromophoric CD exciton chirality principle was develope d to distinguish all four possible stereoisomers nonambiguously at a l evel of ca. 1 microgram.