TRANSFERRIN MICROHETEROGENEITY AS A PROBE IN NORMAL AND DISEASE STATES

Authors
DEJONG G FEELDERS R VANNOORT WL VANEIJK HG
Citation
G. Dejong et al., TRANSFERRIN MICROHETEROGENEITY AS A PROBE IN NORMAL AND DISEASE STATES, Glycoconjugate journal, 12(3), 1995, pp. 219-226
Citations number
26
Categorie Soggetti
Biology
Journal title
Glycoconjugate journal → ACNP
ISSN journal
02820080
Volume
12
Issue
3
Year of publication
1995
Pages
219 - 226
Database
ISI
SICI code
0282-0080(1995)12:3<219:TMAAPI>2.0.ZU;2-T
Abstract
Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebros pinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein syndrome. In normal physiological states it can also be used as a tool to probe for changes in N-glycosylation.