B-50 (GAP-43) IN THE RAT SPINAL-CORD CAUDAL TO HEMISECTION - LACK OF INTRASPINAL SPROUTING BY DORSAL-ROOT AXONS

Authors
NACIMIENTO W SAPPOK T BROOK GA TOTH L OESTREICHER AB GISPEN WH NOTH J KREUTZBERG GW
Citation
W. Nacimiento et al., B-50 (GAP-43) IN THE RAT SPINAL-CORD CAUDAL TO HEMISECTION - LACK OF INTRASPINAL SPROUTING BY DORSAL-ROOT AXONS, Neuroscience letters, 194(1-2), 1995, pp. 13-16
Citations number
25
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
194
Issue
1-2
Year of publication
1995
Pages
13 - 16
Database
ISI
SICI code
0304-3940(1995)194:1-2<13:B(ITRS>2.0.ZU;2-T
Abstract
The controversial hypothesis that intraspinal sprouting by dorsal root axons promotes reinnervation of partially denervated neurons caudal t o a low thoracic cord hemisection was re-investigated in rats using qu antitative immunohistochemical analysis of the neural specific growth- associated protein B-50 (GAP-43) at postoperative survival times of 3, 10, 21, 42, and 90 days. The lack of increase in B-50-immunoreactivit y in all segments below the hemisection at all survival times does not support the concept of intraspinal sprouting following the removal of supraspinal descending pathways.